ABSTRACT: Forty 1-2-y-old water outre x-pression twisted up - passion water wave 24 buffaloes were simultaneously treated with trichlorfon and chlorpyrifos products in the recommended dose for cattle.After a week, 19 animals started presenting clinical signs characterized by apathy, diarrhea, aggressiveness, dehydration, and motor incoordination, followed by flaccid paralysis and permanent lateral recumbency.All affected buffaloes died after a clinical course of 1-4 days.Reduction of serum cholinesterase activity in three cases was indicative of significant exposure southwestern aztec rug to organophosphorus compounds (OPs).Pathological examination of three buffaloes revealed no gross and histological lesions.
By thin layer chromatography, chlorpyrifos residues and trace of trichlorfon residues were detected in fresh tissue samples.The epidemiological, clinical, pathological, and toxicological findings were highly compatible with OPs-induced delayed neurotoxicity, a neurological manifestation rarely described in domestic animals.